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Product Description
TC-E 5002 is an inhibitor of the histone lysine demethylase (KDM) subfamily KDM2/7. It potently inhibits KDM2A, KDM7A and KDM7B with an IC₅₀ of 6.8 μM, 0.2 μM and 1.2 μM respectively. It inhibits the growth of KYSE150 and HeLa cells with GI₅₀ values of 16 µM and 40 µM respectively and arrests cells in the G0/G1 phase of the cell cycle. It inhibits demethylation of H3K27me2 at similar concentrations.
TC-E 5002 is an inhibitor of the histone lysine demethylase (KDM) subfamily KDM2/7. It potently inhibits KDM2A, KDM7A and KDM7B with an IC₅₀ of 6.8 μM, 0.2 μM and 1.2 μM respectively. It inhibits the growth of KYSE150 and HeLa cells with GI₅₀ values of 16 µM and 40 µM respectively and arrests cells in the G0/G1 phase of the cell cycle. It inhibits demethylation of H3K27me2 at similar concentrations.
Biovision | B2856 | TC-E 5002 DataSheet
Alternate Name/Synonyms: 3-[9-cyclopropylnonanoyl(hydroxy)amino]propanoic acid; N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-beta-alanine; 3-(9-cyclopropyl-N-hydroxynonanamido)propanoic acid
Appearance: A crystalline solid
Formulation:
CAS Number: 1453071-47-0
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₅H₂₇NO₄
Molecular Weight: 285.38
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~30 mg/ml in in DMSO, ~50 mg/ml in in Ethanol, ~10 mg/ml in DMF in 0, ~0.25 mg/ml in PBS, pH 7.2 in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of KDM2/7
MDL Number:
PubChem CID: 71735843
SMILES: C1CC1CCCCCCCCC(=O)N(CCC(=O)O)O
InChi: InChI=1S/C15H27NO4/c17-14(16(20)12-11-15(18)19)8-6-4-2-1-3-5-7-13-9-10-13/h13,20H,1-12H2,(H,18,19)
InChi Key: NEHSERYKENINRH-UHFFFAOYSA-N
