Product Description
Tenovin-6 is a SirT2 inhibitor and a p53 activator. It is a water-soluble analog of Tenovin-1. Tenovins inhibit the protein-deacetylase activities of SirT1 and SirT2. The IC₅₀ for inhibiting human SirT1 and SirT2 peptide deacetylase activity is 21 μM and 10 μM respectively. Tenovin-6 potently inhibits the proliferation of diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia cells.
Tenovin-6 is a SirT2 inhibitor and a p53 activator. It is a water-soluble analog of Tenovin-1. Tenovins inhibit the protein-deacetylase activities of SirT1 and SirT2. The IC₅₀ for inhibiting human SirT1 and SirT2 peptide deacetylase activity is 21 μM and 10 μM respectively. Tenovin-6 potently inhibits the proliferation of diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia cells.
Biovision | B2818 | Tenovin-6 DataSheet
Alternate Name/Synonyms: 4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide, 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide, Benzamide, N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
Appearance: Crystalline solid
Formulation:
CAS Number: 1011557-82-6
Structure Available?: True
Peptide sequence:
Salt Form: FALSE
Molecular Formula: C₂₅H₃₄N₄O₂S
Molecular Weight: 454.63
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~20 mg/ml in in DMSO, ~1mg/ml in in Ethanol
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A SirT2 inhibitor and a p53 activator
MDL Number: MFCD11976906
PubChem CID: 24772043
SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C
InChi: InChI=1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32)
InChi Key: BVJSXSQRIUSRCO-UHFFFAOYSA-N