Product Description
Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist (IC₅₀ = 3 nM for rat receptor) and a diuretic agent. It is selective for V2 over V1 receptors (IC₅₀ = 0.58 μM). Used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist (IC₅₀ = 3 nM for rat receptor) and a diuretic agent. It is selective for V2 over V1 receptors (IC₅₀ = 0.58 μM). Used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Biovision | B2583 | Tolvaptan DataSheet
Alternate Name/Synonyms: OPC-41061, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-benzamide, OPC 41061, OPC41061
Appearance: White to off-white solid
Formulation:
CAS Number: 150683-30-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₅ClN₂O₃
Molecular Weight: 448.94
Cell-Permeable?: False
Purity: ≥98%
Solubilities: >100 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: a selective, A competitive arginine vasopressin V2 receptor antagonist
MDL Number:
PubChem CID: 216237
SMILES: CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
InChi: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
InChi Key: