Product Description
BMN-673 is a potent and selective PARP1/2 inhibitor with Ki values of 1.2 and 0.9 nM, respectively. It had no effect on panels of 72 receptors, ion channels, and enzymes. BMN-673 displays selective antitumor cytotoxicity and elicits DNA repair biomarkers at much lower concentrations than earlier generation PARP1/2 inhibitors.
BMN-673 is a potent and selective PARP1/2 inhibitor with Ki values of 1.2 and 0.9 nM, respectively. It had no effect on panels of 72 receptors, ion channels, and enzymes. BMN-673 displays selective antitumor cytotoxicity and elicits DNA repair biomarkers at much lower concentrations than earlier generation PARP1/2 inhibitors.
Biovision | B1861 | BMN-673 DataSheet
Alternate Name/Synonyms: (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-1H-pyrido[4,3,2-de]phthalazin-3(2H)-one; Talazoparib
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1207456-01-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₉H₁₄F₂N₆O
Molecular Weight: 380.35
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective PARP1/2 inhibitor
MDL Number: N/A
PubChem CID: 53345055
SMILES: CN1C(=NC=N1)C2C(N=C3C=C(C=C4C3=C2NNC4=O)F)C5=CC=C(C=C5)F
InChi: InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,25H,1H3,(H,26,28)
InChi Key: IUEWAGVJRJORLA-UHFFFAOYSA-N