Product Description
C-DIM 12 activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NF-kB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells. Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).
C-DIM 12 activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NF-kB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses inflammatory signaling in these cells. Displays neuroprotective activity in a mouse model of progressive neurodegeneration with a strong neuroinflammatory component (50 mg/Kg, oral).
Biovision | B2146 | C-DIM 12 DataSheet
Alternate Name/Synonyms: 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Appearance: Orange powder
Formulation: N/A
CAS Number: 178946-89-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₁₇ClN₂
Molecular Weight: 356.9
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (35 mg/ml) or EtOH (35 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: Orphan nuclear receptor Nurr1 activator
MDL Number: N/A
PubChem CID: 5302583
SMILES: C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)Cl)C4=CNC5=CC=CC=C54
InChi: InChI=1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H
InChi Key: LTLRXTDMXOFBDW-UHFFFAOYSA-N