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Product Description
A cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.
Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain 1 (Ki = 120 nM) and calpain 2 (Ki = 230 nM). Also potently inhibits cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Shown to induce caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin’s Lymphoma cells.
Biovision | 1835 | Calpain Inhibitor II, ALLM DataSheet
Alternate Name/Synonyms: Ac-LLM-CHO, N-Acetyl-Leu-Leu-Methional
Appearance: White powder
Formulation: N/A
CAS Number: 136632-32-1
Structure Available?: Yes
Peptide sequence: N-Acetyl-Leu-Leu-Methional
Salt Form: No
Molecular Formula: C₁₉H₃₅N₃O₄S
Molecular Weight: 401.57
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (25 mg/ml) or EtOH (25 mg/ml)
Handling: Protect from moisture and air
Country of Origin: USA
Tag Line: A Calpain inhibitor
MDL Number: MFCD00065506
PubChem CID: 4331
SMILES: CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C
InChi: InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18 (25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21, 25)(H,22,26)
InChi Key: RJWLAIMXRBDUMH-UHFFFAOYSA-N
