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Product Description
A synthetic peptide inhibitor that irreversibly inhibits caspase-3 and related protease/caspase activity and blocks apoptosis. DEVD is the specific recognition sequence found in poly (ADP-ribose) polymerase (PARP). The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Z-DEVD-FMK is a synthetic peptide, cell-permeable inhibitor that irreversibly inhibits caspase-3 and related protease/caspase activity and blocks apoptosis.
Biovision | 1009 | Caspase-3 Inhibitor Z-DEVD-FMK DataSheet
Alternate Name/Synonyms: Z-DEVD-FMK, Caspase-3 inhibitor, Z-DEVD fluoromethylketone
Appearance: Liquid
Formulation: In DMSO (2 mM)
CAS Number: N/A
Structure Available?: No
Peptide sequence: Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK
Salt Form: No
Molecular Formula: C₃₀H₄₁FN₄O₁₂
Molecular Weight: 668.7
Cell-Permeable?: Yes
Purity: >98% by HPLC
Solubilities: N/A
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: Caspase-3 inhibitor
MDL Number: N/A
PubChem CID: 16760394
SMILES: CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1
InChi: InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
InChi Key: GBJVAVGBSGRRKN-JYEBCORGSA-N
