Product Description
CB5083 is a potent, ATP-competitive, D2-selective, p97 inhibitor (IC₅₀ = 11 nM). In xenograft models, CB-5083 causes modulation of key p97-related pathways, induces apoptosis, and has antitumor activity in a broad range of both hematological and solid tumor models.
CB-5083 is a potent, ATP-competitive, D2-selective, p97 inhibitor (IC₅₀ = 11 nM). In xenograft models, CB-5083 causes modulation of key p97-related pathways, induces apoptosis, and has antitumor activity in a broad range of both hematological and solid tumor models.
Biovision | B1032 | CB5083 DataSheet
Alternate Name/Synonyms: 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1542705-92-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₃N₅O₂
Molecular Weight: 413.47
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP-competitive, D2-selective, p97 inhibitor
MDL Number: N/A
PubChem CID: 73051434
SMILES: CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N
InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28)
InChi Key: RDALZZCKQFLGJP-UHFFFAOYSA-N