Product Description
CCT-241736 is a potent dual FLT3-Aurora inhibitor (IC₅₀ values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively). CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I.
CCT-241736 is a potent dual FLT3-Aurora inhibitor (IC₅₀ values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively). CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I.
Biovision | B2370 | CCT-241736 DataSheet
Alternate Name/Synonyms: CCT241736, 6-chloro-7-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine
Appearance: Crystalline solid
Formulation:
CAS Number: 1402709-93-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₂H₂₃Cl₂N₇
Molecular Weight: 456.38
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >50 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent dual FLT3-Aurora inhibitor
MDL Number:
PubChem CID: 454279
SMILES: CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC5=CC=C(C=C5)Cl)Cl)C
InChi: InChI=1S/C22H23Cl2N7/c1-14-17(13-29(2)28-14)21-26-19-20(18(24)11-25-22(19)27-21)31-9-7-30(8-10-31)12-15-3-5-16(23)6-4-15/h3-6,11,13H,7-10,12H2,1-2H3,(H,25,26,27)
InChi Key: AKJBLKUZXRMECW-UHFFFAOYSA-N