Product Description
CH5424802 is a potent, selective, ATP-competitive inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). It displays potent antitumor activity against RET-rearranged non-small cell lung cancer (NSCLC).
CH5424802 is a potent, selective, ATP-competitive inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). It displays potent antitumor activity against RET-rearranged non-small cell lung cancer (NSCLC).
Biovision | 2867 | CH5424802 DataSheet
Alternate Name/Synonyms: 9-Ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; Alectinib; AF-802
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1256580-46-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₀H₃₄N₄O₂
Molecular Weight: 482.62
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (2 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, selective, ATP-competitive ALK inhibitor
MDL Number: N/A
PubChem CID: 49806720
SMILES: CCC1=C(C=C2C(=C1)C(=O)C3=C(C2(C)C)NC4=C3C=CC(=C4)C#N)N5CCC(CC5)N6CCOCC6
InChi: InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
InChi Key: KDGFLJKFZUIJMX-UHFFFAOYSA-N