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Product Description
Cladribine is an adenosine deaminase inhibitor. It is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase. Cladribine displays selective cytotoxicity against both proliferating and non-dividing lymphocytes. Also displays immunosuppressive activity.
Cladribine is an adenosine deaminase inhibitor. It is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase. Cladribine displays selective cytotoxicity against both proliferating and non-dividing lymphocytes. Also displays immunosuppressive activity.
Biovision | B2037 | Cladribine DataSheet
Alternate Name/Synonyms: 2-Chloro-2'-deoxy-adenosine; NSC105014; RWJ 26251
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 4291-63-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₀H₁₂ClN₅O₃
Molecular Weight: 285.7
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An adenosine deaminase inhibitor
MDL Number: MFCD00153939
PubChem CID: 20279
SMILES: C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O
InChi: InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChi Key: PTOAARAWEBMLNO-KVQBGUIXSA-N
