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Product Description
CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203 arrests the growth of leukemic T cells in vitro (EC₅₀ = 91 nM) and rapidly suppresses leukemia burden in mice.
CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203 arrests the growth of leukemic T cells in vitro (EC₅₀ = 91 nM) and rapidly suppresses leukemia burden in mice.
Biovision | 9404 | CPI-203 DataSheet
Alternate Name/Synonyms: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Appearance: White solid
Formulation: N/A
CAS Number: 1446144-04-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₈ClN₅OS
Molecular Weight: 399.9
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>35 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A BET bromodomain inhibitor
MDL Number: N/A
PubChem CID: 71291068
SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C
InChi: InChI=1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1
InChi Key: QECMENZMDBOLDR-AWEZNQCLSA-N
