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Product Description
Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver.
Dextromethorphan (DXM) is a morphinan used as a cough suppressant. It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver.
Biovision | 2912 | Dextromethorphan (hydrobromide hydrate) DataSheet
Alternate Name/Synonyms: (9α,13α,14α)-3-methoxy-17-methyl-morphinan, hydrobromide monohydrate
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 6700-34-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₂₅NO • HBr [H₂O]
Molecular Weight: 370.3
Cell-Permeable?: N/A
Purity: ≥98%
Solubilities: PBS, pH 7.2 (5 mg/ml), Ethanol or DMF (20 mg/ml), DMSO (12 mg/ml). Organic solvents should be purged in inert gas. Aqueous solutions should not be stored for >1 day.
Handling: Do not take internally. Wear gloves and mask when handling! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A Cytochrome P450 2D6 substrate
MDL Number: MFCD02173901
PubChem CID: 5462351
SMILES: CN1[C@@H]2[C@@]3([H])CCCC[C@@]3(CC1)C4=CC(OC)=CC=C4C2
InChi: InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
InChi Key: MKXZASYAUGDDCJ-NJAFHUGGSA-N
