Product Description
Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. Ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis.
Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. Ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis.
Biovision | B1266 | Ethynylcytidine DataSheet
Alternate Name/Synonyms: 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine; TAS-106
Appearance: Crystaline solid
Formulation: N/A
CAS Number: 180300-43-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₁H₁₃N₃O₅
Molecular Weight: 267.24
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An anticancer agent
MDL Number: N/A
PubChem CID: 176885
SMILES: C#CC1(C(OC(C1O)N2C=CC(=NC2=O)N)CO)O
InChi: InChI=1S/C11H13N3O5/c1-2-11(18)6(5-15)19-9(8(11)16)14-4-3-7(12)13-10(14)17/h1,3-4,6,8-9,15-16,18H,5H2,(H2,12,13,17)/t6-,8+,9-,11-/m1/s1
InChi Key: JFIWEPHGRUDAJN-DYUFWOLASA-N