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Product Description
Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently inhibits Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.
Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently inhibits Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.
Biovision | 2871 | Filgotinib DataSheet
Alternate Name/Synonyms: N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide; GLPG0634
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1206161-97-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₂₃N₅O₃S
Molecular Weight: 425.5
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective JAK1 inhibitor
MDL Number: N/A
PubChem CID: 49831257
SMILES: C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5
InChi: InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
InChi Key: RIJLVEAXPNLDTC-UHFFFAOYSA-N
