Product Description
A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
GDC-0449 is a potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.
Biovision | 1890 | GDC-0449 DataSheet
Alternate Name/Synonyms: 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 879085-55-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₄Cl₂N₂O₃S
Molecular Weight: 421.3
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Smoothened (Smo) antagonist
MDL Number: MFCD12407408
PubChem CID: 24776445
SMILES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
InChi: InChI=1S/C19H14Cl2N2O3S/c1-27(25, 26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22- 18/h2-11H,1H3,(H,23,24)
InChi Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N