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Product Description
GPNA is a substrate for γ-glutamyl transpeptidase. GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5). Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.
GPNA is a substrate for γ-glutamyl transpeptidase. GPNA has also been shown to be an inhibitor of glutamine uptake - solute-linked carrier family A1 member 5 (SLC1A5). Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.
Biovision | B2150 | GPNA (monohydrate) DataSheet
Alternate Name/Synonyms: (L-γ-Glutamyl-p-nitroanilide, L-Glutamic acid 5-(4-nitroanilide)
Appearance: White to green yellow solid
Formulation: N/A
CAS Number: 7300-59-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₁H₁₃N₃O₅.H₂O
Molecular Weight: 285.25
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A glutamine uptake inhibitor
MDL Number: MFCD00036218
PubChem CID: N/A
SMILES: O=C(Nc1ccc(cc1)[N+]([O-])=O)CC[C@H](N)C(=O)O
InChi: InChI=1S/C11H13N3O5/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17)/t9-/m0/s1
InChi Key: WMZTYIRRBCGARG-VIFPVBQESA-N
