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Product Description
GSK-2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) (IC₅₀ = 10 nM). It does not suppress activity on other 96 kinases, including Aurora, ROCK, p38 MAPK and PI3K.
GSK-2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1) (IC₅₀ = 10 nM). It does not suppress activity on other 96 kinases, including Aurora, ROCK, p38 MAPK and PI3K.
Biovision | B1555 | GSK-2334470 DataSheet
Alternate Name/Synonyms: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide
Appearance: Light yellow solid
Formulation: N/A
CAS Number: 1227911-45-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₅H₃₄N₈O
Molecular Weight: 462.59
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>40 mg/ml) or EtOH (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1)
MDL Number: N/A
PubChem CID: 46215815
SMILES: CC1CCC(CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5
InChi: InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31
InChi Key: QLPHOXTXAKOFMU-WBVHZDCISA-N
