Product Description
IKK-16 is a potent and selective inhibitor of IκB kinase (IKK) with IC₅₀ values from 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. It is effective in cells and in animals and has been used delineate the role of NF-κB signaling in diverse contexts. IKK-16 has also been reported to inhibit protein kinase D isoforms and the ATP-binding cassette (ABC) transporter ABCB1.
IKK-16 is a potent and selective inhibitor of IκB kinase (IKK) with IC₅₀ values from 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively. It is effective in cells and in animals and has been used delineate the role of NF-κB signaling in diverse contexts. IKK-16 has also been reported to inhibit protein kinase D isoforms and the ATP-binding cassette (ABC) transporter ABCB1.
Biovision | B1087 | IKK16 DataSheet
Alternate Name/Synonyms: [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone, hydrochloride
Appearance: Beige solid
Formulation: N/A
CAS Number: 1186195-62-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₈H₃₀ClN₅OS
Molecular Weight: 520.09
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: IKK-16 is a potent and selective inhibitor of IκB kinase (IKK)
MDL Number: MFCD09971091
PubChem CID: 56972179
SMILES: C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl
InChi: InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H
InChi Key: XFVDIVQCZWDBCW-UHFFFAOYSA-N