Product Description
Ingenol is a diterpenoid related to phorbol that acts as a weak protein kinase C (PKC) activator that displays a Ki value of 30 μM and an ED₅₀ value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.
Ingenol is a diterpenoid related to phorbol that acts as a weak protein kinase C (PKC) activator that displays a Ki value of 30 μM and an ED₅₀ value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.
Biovision | 2527 | Ingenol DataSheet
Alternate Name/Synonyms: (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 30220-46-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C20H28O5
Molecular Weight: 348.44
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO or EtOH
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A protein kinase C (PKC) activator
MDL Number: MFCD00056380
PubChem CID: 442042
SMILES: CC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4O)C)O)O)CO
InChi: InChI=1S/C20H28O5/c1-9-7-19-10(2)5-13-14(18(13,3)4)12(17(19)24)6-11(8-21)16(23)20(19,25)15(9)22/h6-7,10,12-16,21-23,25H,5,8H2,1-4H3/t10-,12+,13-,14+,15+,16-,19+,20-/m1/s1
InChi Key: EBVPUXQAPLADL-POYOOMFHSA-N