Product Description
ITF2357 is an orally active, hydroxamic-containing pan-histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity in human peripheral blood mononuclear cells and the secretion of IL-1β and other cytokines at 25-100 nM.
ITF2357 is an orally active, hydroxamic-containing pan-histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity in human peripheral blood mononuclear cells and the secretion of IL-1β and other cytokines at 25-100 nM.
Biovision | 9431 | ITF2357 DataSheet
Alternate Name/Synonyms: [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride, monohydrate; Givinostat
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 732302-99-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₇N₃O₄.HCl.H₂O
Molecular Weight: 475.97
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A pan-HDAC inhibitor
MDL Number: N/A
PubChem CID: 9804991
SMILES: CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl
InChi: InChI=1S/C24H27N3O4.ClH.H2O/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H;1H2
InChi Key: FKGKZBBDJSKCIS-UHFFFAOYSA-N