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Product Description
An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM).
Biovision | 2349 | IWP-3 DataSheet
Alternate Name/Synonyms: Inhibitor of Wnt Production-3; 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2- d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide
Appearance: White to Off-white Solid
Formulation: N/A
CAS Number: 687561-60-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₁₇FN₄O₂S₃
Molecular Weight: 484.59
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~2 mg/ml on warming)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An inhibitor of Wnt production
MDL Number: MFCD04457889
PubChem CID: N/A
SMILES: O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=C(F)C=C5)=O
InChi: InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
InChi Key: XVMHQSDMKWQNBK-UHFFFAOYSA-N
