Product Description
Cell-permeable. KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀= 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC₅₀ = 15 nM).
KN-62 is a selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaMKII; IC₅₀ = 900 nM). It binds directly to the calmodulin binding site of the enzyme. It does not affect the activity of several other kinases when tested at 10 µM.
Biovision | 2495 | KN-62 DataSheet
Alternate Name/Synonyms: 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 5-isoquinolinesulfonic acid
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 127191-97-3
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₈H₃₅N₅O₆S₂
Molecular Weight: 721.84
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II
MDL Number: MFCD00083180
PubChem CID: 5312126
SMILES: CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7
InChi: InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1
InChi Key: RJVLFQBBRSMWHX-DHUJRADRSA-N