Euro
USD
British Pound
NULL
Product Description
A pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for inhibition of neuronal and endothelial NOS isoforms (Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively). L-NAME inhibits cGMP formation in endothelial cells with an IC₅₀ of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 µM.
L-NAME is a pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for inhibition of neuronal and endothelial NOS isoforms (Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively).
Biovision | 2356 | L-NAME hydrochloride DataSheet
Alternate Name/Synonyms: NG-Nitro-L-arginine methyl ester hydrochloride
Appearance: White solid
Formulation: N/A
CAS Number: 51298-62-5
Structure Available?: Yes
Peptide sequence: H-Arg(NO2)-OMeHCl
Salt Form: Yes
Molecular Formula: C₇H₁₅N₅O₄.HCl
Molecular Weight: 269.69
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~ 5 mg/ml) or H2O (~50 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A pro-drug of the NOS inhibitor L- NG-Nitro-L-arginine
MDL Number: MFCD00039052
PubChem CID: 135193
SMILES: COC(=O)C(CCCN=C(N)N[N+](=O)[O-])N.Cl
InChi: InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChi Key: QBNXAGZYLSRPJK-JEDNCBNOSA-N
