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Product Description
LY411575 is a potent, cell-permeable γ-secretase inhibitor (IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC₅₀ of 0.39 nM. Notch inhibition using LY-411575 induces cochlear hair cell regeneration and recovery of hearing in mice after acoustic trauma.
LY411575 is a potent, cell-permeable γ-secretase inhibitor (IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC₅₀ of 0.39 nM. Notch inhibition using LY-411575 induces cochlear hair cell regeneration and recovery of hearing in mice after acoustic trauma.
Biovision | 2648 | LY-411575 DataSheet
Alternate Name/Synonyms: N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide; LSN-411575
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 209984-57-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₃F₂N₃O₄
Molecular Weight: 479.48
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent γ-secretase inhibitor
MDL Number: N/A
PubChem CID: 10435235
SMILES: CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
InChi: InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1
InChi Key: ULSSJYNJIZWPSB-CVRXJBIPSA-N
