Product Description
MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Biovision | B1942 | MK-8745 DataSheet
Alternate Name/Synonyms: (3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 885325-71-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₁₉ClFN₅OS
Molecular Weight: 431.91
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>18 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An Aurora-A specific inhibitor
MDL Number: N/A
PubChem CID: 11676373
SMILES: C1CN(CCN1CC2=NC(=CC=C2)NC3=NC=CS3)C(=O)C4=C(C(=CC=C4)Cl)F
InChi: InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)
InChi Key: YCRFPWKUUNKNDN-UHFFFAOYSA-N