Product Description
Cell-permeable. ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC₅₀ = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC₅₀ ~ 10 µM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons.
ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC₅₀ = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC₅₀ ~ 10 µM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons.
Biovision | 2763 | ML-324 DataSheet
Alternate Name/Synonyms: N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
Appearance: Light brown solid
Formulation: N/A
CAS Number: 1222800-79-4
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₂₃N₃O₂
Molecular Weight: 349.43
Cell-Permeable?: Y
Purity: ≥98% by TLC
Solubilities: DMSO (~ 20 mg/ml, warm) or EtOH (~ 6 mg/ml, warm)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: AJMJD2 histone demethylase inhibitor
MDL Number: MFCD28053518
PubChem CID: N/A
SMILES: OC1=CC(C2=CC=C(C(NCCCN(C)C)=O)C=C2)=CC3=CC=CN=C31
InChi: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N