Product Description
Netarsudil Hydrochloride (AR-13324) is a Rho kinase (ROCK) inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous humor. Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; a novel ocular hypotensive agent for the treatment of glaucoma.
Netarsudil Hydrochloride (AR-13324) is a Rho kinase (ROCK) inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous humor. Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; a novel ocular hypotensive agent for the treatment of glaucoma.
Biovision | B2387 | Netarsudil dihydrochloride DataSheet
Alternate Name/Synonyms: [4-[(2~{S})-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate;dihydrochloride, AR-13324 hydrochloride
Appearance: Crystalline solid
Formulation:
CAS Number: 1253952-02-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₈H₂₉Cl₂N₃O₃
Molecular Weight: 526.46
Cell-Permeable?: TRUE
Purity: ≥98% by HPLC
Solubilities: >20 mg/ml in Water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent, selective ROCK inhibitor
MDL Number:
PubChem CID: 66599892
SMILES: CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl
InChi: InChI=1S/C28H27N3O3.2ClH/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;;/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H/t26-;;/m1../s1
InChi Key: LDKTYVXXYUJVJM-FBHGDYMESA-N