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Product Description
Cell-permeable. Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
NSC 66811 Potent MDM2 (murine double minute 2) inhibitor (Ki = 120 nM) that disrupts MDM2-p53 interaction and activates p53 in cancer cells. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
Biovision | 2009 | NSC 66811 DataSheet
Alternate Name/Synonyms: 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Appearance: White solid
Formulation: N/A
CAS Number: 6964-62-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₀N₂O
Molecular Weight: 340.42
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: DMSO (~ 100 mM)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: Potent MDM2 inhibitor
MDL Number: N/A
PubChem CID: 248986
SMILES: CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
InChi: InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4- 2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
InChi Key: WEENRMPCSWFMTE-UHFFFAOYSA-N
