Product Description
Oxythiamine is a thiamine antagonist that acts as a transketolase inhibitor. As transketolase is a crucial enzyme of the pentose phosphate pathway, inhibition of this enzyme causes suppression of the pentose phosphate pathway and thus deprives cells of the metabolic intermediate (glyceraldehyde-3-phosphate) for ATP generation and of the substrates (NADPH, ribose-phosphate) for macromolecule synthesis. This metabolic inhibition seems to be responsible, at least in part, for the significant anticancer activity observed in vitro and in vivo.
Oxythiamine is a thiamine antagonist that acts as a transketolase inhibitor. As transketolase is a crucial enzyme of the pentose phosphate pathway, inhibition of this enzyme causes suppression of the pentose phosphate pathway and thus deprives cells of the metabolic intermediate (glyceraldehyde-3-phosphate) for ATP generation and of the substrates (NADPH, ribose-phosphate) for macromolecule synthesis. This metabolic inhibition seems to be responsible, at least in part, for the
Biovision | B1046 | Oxythiamine Chloride Hydrochloride DataSheet
Alternate Name/Synonyms: 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
Appearance: White solid
Formulation: N/A
CAS Number: 614-05-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₂H₁₆ClN₃O₂S.HCl
Molecular Weight: 338.25
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A thiamine antagonist that acts as a transketolase inhibitor.
MDL Number: MFCD00050656
PubChem CID: 56845140
SMILES: CC1=C(SC=[N+]1CC2=CN=C(N=C2N=O)C)CCO.Cl.[Cl-]
InChi: InChI=1S/C12H15N4O2S.2ClH/c1-8-11(3-4-17)19-7-16(8)6-10-5-13-9(2)14-12(10)15-18;;/h5,7,17H,3-4,6H2,1-2H3;2*1H/q+1;;/p-1
InChi Key: BNURZUBKXXZBQE-UHFFFAOYSA-M