Product Description
An anti-inflammatory agent. Specifically inhibits activation of NF-κB by preventing the degradation of IκBα and IκBβ. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2. Potent anticancer agent. Induces apoptosis in various cancer cell lines. Specifically inhibits histone deacetylase 1 (HDAC1) without affecting other class I/II HDACs.
Parthenolide is an anti-inflammatory agent. Specifically inhibits activation of NF-κB by preventing the degradation of IκBα and IκBβ. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2. Potent anticancer agent.
Biovision | 1868 | Parthenolide DataSheet
Alternate Name/Synonyms: (1aR-[1aR*,4E,7aS*,-10aS*,-10bR*])-2,3-6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 20554-84-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₂₀O₃
Molecular Weight: 248.32
Cell-Permeable?: Yes
Purity: ≥97% by TLC
Solubilities: DMSO (100 mg/ml) or EtOH (20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A NF-κB activation inhibitor
MDL Number: MFCD00134592
PubChem CID: 7251185
SMILES: CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
InChi: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
InChi Key: KTEXNACQROZXEV-PVLRGYAZSA-N