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Product Description
PCI 34051 is a potent histone deacetylase 8 (HDAC8) inhibitor (IC₅₀ = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC₅₀s = 4, >50, >50, 2.9, and 13 μM, respectively).
Cell-permeable. A potent histone deacetylase 8 (HDAC8) inhibitor (IC₅₀ = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC₅₀s = 4, >50, >50, 2.9, and 13 μM, respectively). It inhibits cell growth and induces apoptosis only in T-cell-derived tumor lines, such as Jurkat and Hut78, but not in solid tumor lines, or in other hematopoietic tumors such as those derived from B cells, plasma cells or monocytes.
Biovision | 2251 | PCI 34051 DataSheet
Alternate Name/Synonyms: N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
Appearance: White to Off-white Solid
Formulation: N/A
CAS Number: 950762-95-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₆N₂O₃
Molecular Weight: 296.32
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A potent HDAC8 inhibitor
MDL Number: MFCD11114393
PubChem CID: 24753719
SMILES: COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO
InChi: InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
InChi Key: AJRGHIGYPXNABY-UHFFFAOYSA-N
