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Product Description
(R,R)-Hymeglusin is a specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the enzyme. It is a fungal beta-lactone that inhibits mevalonate biosynthesis and is a good target for statins. It displays antimicrobial and anti-fungal activity.
(R,R)-Hymeglusin is a specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the enzyme. It is a fungal beta-lactone that inhibits mevalonate biosynthesis and is a good target for statins. It displays antimicrobial and anti-fungal activity.
Biovision | B1244 | (R,R)-Hymeglusin DataSheet
Alternate Name/Synonyms: (2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 29066-42-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₂₈O₅
Molecular Weight: 324.41
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A specific and irreversable inhibitor of HMG-CoA
MDL Number: MFCD01940046
PubChem CID: 6440895
SMILES: CC(CCCCC1C(C(=O)O1)CO)CC(=CC(=CC(=O)O)C)C
InChi: InChI=1S/C18H28O5/c1-12(8-13(2)9-14(3)10-17(20)21)6-4-5-7-16-15(11-19)18(22)23-16/h9-10,12,15-16,19H,4-8,11H2,1-3H3,(H,20,21)/b13-9+,14-10+/t12-,15-,16-/m1/s1
InChi Key: ODCZJZWSXPVLAW-KXCGKLMDSA-N
