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Product Description
Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
ARO 20-1724 is a potent, selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
Biovision | 2042 | RO 20-1724 DataSheet
Alternate Name/Synonyms: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 29925-17-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₅H₂₂N₂O₃
Molecular Weight: 278.35
Cell-Permeable?: Yes
Purity: ≥99% by TLC
Solubilities: DMSO (~200 mg/ml) or Ethanol (~40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent PDEIV inhibitor
MDL Number: MFCD00077397
PubChem CID: 5087
SMILES: CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC
InChi: InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
InChi Key: PDMUULPVBYQBBK-UHFFFAOYSA-N
