Euro
USD
British Pound
NULL
Product Description
SB-415286 is a potent, selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α). Displays minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
SB-415286 is a potent, selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α). Displays minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
Biovision | B1954 | SB-415286 DataSheet
Alternate Name/Synonyms: 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Appearance: Yellow solid
Formulation: N/A
CAS Number: 264218-23-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₀ClN₃O₅
Molecular Weight: 359.73
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, selective and ATP-competitive, glycogen synthase kinase-3 (GSK-3) inhibitor
MDL Number: MFCD04039789
PubChem CID: 4210951
SMILES: C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]
InChi: InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
InChi Key: PQCXVIPXISBFPN-UHFFFAOYSA-N
