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Product Description
SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.
SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.
Biovision | B1580 | SC-26196 DataSheet
Alternate Name/Synonyms: 2,2-diphenyl-5-[4-(pyridin-3-ylmethylideneamino)piperazin-1-yl]pentanenitrile
Appearance: Beige solid
Formulation: N/A
CAS Number: 218136-59-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₇H₂₉N₅
Molecular Weight: 423.55
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective Δ6 desaturase inhibitor
MDL Number: MFCD11226148
PubChem CID: 9845201
SMILES: C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4
InChi: C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CN=CC=C4
InChi Key: QFYKXKMYVYOUNJ-JBASAIQMSA-N
