Product Description
SD208 is a potent, ATP-competitive transforming growth factor-β receptor 1 (TGF-βR1) kinase inhibitor (IC₅₀ = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
SD208 is a potent, ATP-competitive transforming growth factor-β receptor 1 (TGF-βR1) kinase inhibitor (IC₅₀ = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biovision | 2885 | SD208 DataSheet
Alternate Name/Synonyms: 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
Appearance: Light brown solid
Formulation: N/A
CAS Number: 627536-09-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₀ClFN₆
Molecular Weight: 352.75
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent TGF-βR1 kinase inhibitor
MDL Number: MFCD11519969
PubChem CID: 10316032
SMILES: C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
InChi: InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChi Key: BERLXWPRSBJFHO-UHFFFAOYSA-N