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Product Description
Skepinone-L is a potent, ATP-competitive inhibitor of p38 MAPK isoform p38α (IC₅₀ = 5 nM) and p38β (97% inhibition at 1 µM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin (Cat. No. 1549) in HeLa cells (IC₅₀ = 25 nM) or TNF-α in THP-1 cells.
Skepinone-L is a potent, ATP-competitive inhibitor of p38 MAPK isoform p38α (IC₅₀ = 5 nM) and p38β (97% inhibition at 1 µM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin (Cat. No. 1549) in HeLa cells (IC₅₀ = 25 nM) or TNF-α in THP-1 cells.
Biovision | B1110 | Skepinone-L DataSheet
Alternate Name/Synonyms: 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one
Appearance: Yellow solid
Formulation: N/A
CAS Number: 1221485-83-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₁F₂NO₄
Molecular Weight: 425.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~15 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP-competitive inhibitor of p38 MAPK isoform p38α
MDL Number: N/A
PubChem CID: 45279963
SMILES: C1CC2=C(C=CC(=C2)NC3=C(C=C(C=C3)F)F)C(=O)C4=C1C=CC(=C4)OCC(CO)O
InChi: InChI=1S/C24H21F2NO4/c25-16-4-8-23(22(26)10-16)27-17-5-7-20-15(9-17)2-1-14-3-6-19(11-21(14)24(20)30)31-13-18(29)12-28/h3-11,18,27-29H,1-2,12-13H2/t18-/m1/s1
InChi Key: HXMGCTFLLWPVFM-GOSISDBHSA-N
