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Product Description
A potent and selective inhibitor of fibroblast growth factor receptor (FGFR) (IC₅₀ = 0.03 µM for FGFR1) and vascular endothelial growth factor receptors (VEGFR) (IC₅₀ = 0.02 µM for VEGFR2). In addition, integrin β4-induced differentiation of neural stem cells was attenuated by SU 5402.
SU-5402 is a potent and selective inhibitor of fibroblast growth factor receptor (FGFR) (IC₅₀ = 0.03 µM for FGFR1) and vascular endothelial growth factor receptors (VEGFR) (IC₅₀ = 0.02 µM for VEGFR2).
Biovision | 1645 | SU-5402 DataSheet
Alternate Name/Synonyms: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-meth yl-1H-pyrrole-3-propanoic acid
Appearance: Yellow solid
Formulation: N/A
CAS Number: 215543-92-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₆N₂O₃
Molecular Weight: 296.32
Cell-Permeable?: No
Purity: ≥97% by HPLC
Solubilities: DMSO (100 mM) )
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A FGFR inhibitor
MDL Number: MFCD08235144
PubChem CID: 5289418
SMILES: CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
InChi: InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChi Key: JNDVEAXZWJIOKB-JYRVWZFOSA-N
