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Product Description
Cell-permeable. A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC₅₀ values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.
SU 6668 is a potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC₅₀ values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.
Biovision | 1931 | SU 6668 DataSheet
Alternate Name/Synonyms: 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Appearance: Orange red solid
Formulation: N/A
CAS Number: 252916-29-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₈N₂O₃
Molecular Weight: 310.35
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~100 mM)
Handling: Protect from light
Country of Origin: USA
Tag Line: A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases
MDL Number: MFCD00149792
PubChem CID: 5995546
SMILES: CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O
InChi: InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6- 15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9+
InChi Key: NHFDRBXTEDBWCZ-NTEUORMPSA-N
