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Product Description
Cell-permeable. A potent inhibitor of Fms-like tyrosine kinase 3 (FLT3) kinase, PDGFRβ and c-Kit (IC50’s 95-122 ng/ml). It inhibits FLT3 phosphorylation, downstream signaling and tumor growth in vitro and in animal models.
Tandutinib is a potent inhibitor of Fms-like tyrosine kinase 3 (FLT3) kinase, PDGFRβ and c-Kit (IC50’s 95-122 ng/ml). It inhibits FLT3 phosphorylation, downstream signaling and tumor growth in vitro and in animal models.
Biovision | 2024 | Tandutinib DataSheet
Alternate Name/Synonyms: MLN518; CT53518
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 387867-13-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₁H₄₂N₆O₄
Molecular Weight: 562.7
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 25 mg/ml) or EtOH (~ 25 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent inhibitor of FLT kinase, PDGFRβ and c-Kit
MDL Number: MFCD09954147
PubChem CID: 3038522
SMILES: CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5
InChi: InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36 (16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4- 6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
InChi Key: UXXQOJXBIDBUAC-UHFFFAOYSA-N
