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Product Description
TCS-359 is a potent, ATP-competitive inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. It blocks the proliferation of myelomonocytic leukemia MV4-11 cells. TCS-359 synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.
TCS-359 is a potent, ATP-competitive inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. It blocks the proliferation of myelomonocytic leukemia MV4-11 cells. TCS-359 synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.
Biovision | B2212 | TCS-359 DataSheet
Alternate Name/Synonyms: 2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
Appearance: White solid
Formulation: N/A
CAS Number: 301305-73-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₂₀N₂O₄S
Molecular Weight: 360.43
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP-competitive FLT3 receptor tyrosine kinase inhibitor
MDL Number: N/A
PubChem CID: 1048845
SMILES: COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC
InChi: InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChi Key: FSPQCTGGIANIJZ-UHFFFAOYSA-N
