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Product Description
Verapamil is a L-type Calcium channel blocker. It has both peripheral and coronary vasodilator effects (IC₅₀ = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches. Verapamil also acts as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell line.
Verapamil is a L-type Calcium channel blocker. It has both peripheral and coronary vasodilator effects (IC₅₀ = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches. Verapamil also acts as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell line.
Biovision | 2861 | Verapamil hydrochloride DataSheet
Alternate Name/Synonyms: α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile hydrochloride
Appearance: White solid
Formulation: N/A
CAS Number: 152-11-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₃₈N₂O₄.HCl
Molecular Weight: 491.07
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: Water (>40 mg/ml) or DMSO (>20 mg/ml) or EtOH (>20 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A L-type calcium channel blocker
MDL Number: MFCD0005528
PubChem CID: 62969
SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
InChi: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChi Key: DOQPXTMNIUCOSY-UHFFFAOYSA-N
