Product Description
WZ-8040 is a potent EGFR inhibitor that suppresses the growth of EGFR-T790M (a mutation of the gatekeeper T790 residue) containing cell lines and inhibits EGFR phosphorylation.
WZ-8040 is a potent EGFR inhibitor that suppresses the growth of EGFR-T790M (a mutation of the gatekeeper T790 residue) containing cell lines and inhibits EGFR phosphorylation.
Biovision | B2205 | WZ-8040 DataSheet
Alternate Name/Synonyms: N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1214265-57-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₅ClN₆OS
Molecular Weight: 481.01
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent EGFR inhibitor
MDL Number: N/A
PubChem CID: 44607531
SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl
InChi: InChI=1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
InChi Key: KIISCIGBPUVZBF-UHFFFAOYSA-N