Euro
USD
British Pound
NULL
Product Description
Zotarolimus is a semi-synthetic derivative of Sirolimus (Cat. No. 1568) that acts as an immunosuppressant. Zotarolimus displays meachanism similar to sirolimus in having high-affinity binding to the immunophilin FKBP12 and comparable potency for inhibiting in vitro proliferation of both human and rat T cells. In vitro, zotarolimus inhibited FKBP-12 binding (IC50 = 2.8 nM) and potently blocked smooth muscle cell (IC₅₀ = 2.9 nM) and endothelial cell (IC₅₀ = 2.6 nM) proliferation.
Zotarolimus is a semi-synthetic derivative of Sirolimus (Cat. No. 1568) that acts as an immunosuppressant. Zotarolimus displays meachanism similar to sirolimus in having high-affinity binding to the immunophilin FKBP12 and comparable potency for inhibiting in vitro proliferation of both human and rat T cells. In vitro, zotarolimus inhibited FKBP-12 binding (IC50 = 2.8 nM) and potently blocked smooth muscle cell (IC₅₀ = 2.9 nM) and endothelial cell (IC₅₀ = 2.6 nM) proliferation.
Biovision | 9530 | Zotarolimus DataSheet
Alternate Name/Synonyms: P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid; L 758298;
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 221877-54-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₅₂H₇₉N₅O₁₂
Molecular Weight: 966.21
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An immunosuppressant
MDL Number: N/A
PubChem CID: 9876378
SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)N5C=NN=N5)C)C)O)OC)C)C)C)OC
InChi: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@@H]([C@@H](C4)OC)N5C=NN=N5)C)/C)O)OC)C)C)/C)OC
InChi Key: CGTADGCBEXYWNE-JUKNQOCSSA-N
