Product Description
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. Isoform Bcl-X(S) promotes apoptosis.
Biovision | 7885 | Active BCL2L1 Protein human recombinant DataSheet
Biomolecule/Target: BCL2L1
Synonyms: Bcl-2-like protein 1, Bcl2-L-1, Bcl-X, BCL2L, BCLX
Alternates names: Bcl-2-like protein 1, Bcl2-L-1, Bcl-X, BCL2L, BCLX
Taglines: A Potent inhibitor of cell death that inhibits the activation of caspases.
NCBI Gene ID #: 25608
NCBI Gene Symbol: LEP
Gene Source: Human
Accession #: P50596
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: The ED determined by the leptin-dependent stimulation of human OB-R transfected murine BaF3 indicator cells is 0.35-0.06 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 16.2 kDa
Concentration: N/A
Appearance: Dry powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.11.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for three months. For long-term storage it is recommended to add a carrier protein (0.1% HAS or BSA).
Amino acid sequence: N/A