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Product Description
Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.
Biovision | 7294 | Alpha 1 Antitrypsin Human Plasma DataSheet
Biomolecule/Target: Serpin A1
Synonyms: Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Alternates names: Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Taglines: An acute-phase plasma protein
NCBI Gene ID #: 5265
NCBI Gene Symbol: Serpin A1
Gene Source: Human
Accession #: P01009
Recombinant: No
Source: Human Plasma
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Shows 75-100% inhibition when tested with active-site titrated porcine pancreatic trypsin using Na-Benzoyl-L-Arginine-para-Nitroanilide Hydrochloride (L-BAPNA) as substrate.
Results: 5.0 IU/mg
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 52 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.
Reconstitution Instructions: In water or aqueous buffer
Amino acid sequence: N/A
