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Product Description
CA8 was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, this protein lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). It continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3). Recombinant human CA8 protein fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Biovision | P1047 | Carbonic anhydrase-8 human recombinant DataSheet
Biomolecule/Target: CA8
Synonyms: CA-VIII, CALS, CAMRQ3, CARP, CA8
Alternates names: Melanoma differentiation association like protein, MDA1, NG.1, ZMDA1, IL-10C, IL-19
Taglines: A protein lacks carbonic anhydrase activity, involved in Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3).
NCBI Gene ID #: 29949
NCBI Gene Symbol: IL19
Gene Source: Human
Accession #: Q9UHD0
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): Measured by its ability to hydrolyze 1.0 pmole of 4-nitrophenyl acetate to 4-nitrophenol per minute at pH 7.5 at 37C.
Biological activity: Test in process
Results: >450 pmol/min/ug
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 17.9 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 20% glycerol
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1 to 1.0 g/l. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum.
Amino acid sequence: N/A
