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Product Description
Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimers plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers.
Biovision | 1022 | Cathepsin D active human DataSheet
Biomolecule/Target: Cathepsin D
Synonyms: Cathepsin D (active, human)
Alternates names: Cathepsin D
Taglines: An active Lysosomal aspartyl protease
NCBI Gene ID #: 5909
NCBI Gene Symbol: RARRES2
Gene Source: Human
Accession #: Q99969
Recombinant: No
Source: Human liver
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: N/A
Activity (Specifications/test method): 365 units/mg
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: >300 units/mg protein. One unit is defined as the amount of enzyme that digests hemoglobin releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37°C. Substrate: acid denatured hemoglobin (0.2% in reaction mixture). Buffer: 100 mM formate. pH 3.3.
Molecular Weight: N/A
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from a solution containing 2 mM sodium phosphate, pH 6.5
Reconstitution Instructions: Reconstitute the vial in HO to a concentration of 0.1-1 µg/µl. Aliquot and refreeze at -80°C immediately for future use.
Amino acid sequence: N/A
