Product Description
CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator. CIRBP can bind the 3'untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-B signaling as opposed to IL1B mRNA stability directly.
Biovision | 7589 | CIRBP / Cold-inducible RNA-binding protein human recombinant DataSheet
Biomolecule/Target: CIRBP
Synonyms: A18HNRNP, CIRP, CIRBP
Alternates names: bone morphogenetic protein 3, Osteogenin, BMP-3A
Taglines: Plays a protective role in the genotoxic stress response
NCBI Gene ID #: 651
NCBI Gene Symbol: BMP3
Gene Source: Human
Accession #: M22491
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per g of the protein as determined by the LAL method.
Activity (Specifications/test method): N/A
Biological activity: Testing is in progress.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 31.6 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.25 M Imidazole, 20% glycerol.
Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in HO containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.
Amino acid sequence: N/A